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The research base is growing

Notably, the heterogeneous regulation of metabolism across different tissues and organ systems involving genetics, environment, and sex, among other factors, remains relatively under-studied

Table 1 includes preclinical studies of dual and triple use of GLP1 receptor co-agonists in T2DM and obesity [83]

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Furthermore, AST causes a decrease in cytokines via inhibition of the MAPK signaling pathway by reducing the induction and expression of extracellular-signal-regulated kinase (ERK1/2), c-Jun N-terminal kinases (JNK), and p38 MAP Kinase (19, 23)

Applications encompass stroke recovery research, neurodegenerative disease prevention, and cognitive aging investigations